Valproate Induced Hyperammonemic Delirium
Published: December 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.6883
Anupama Muraleedharan, Dhanya Sasidharan Palappallil, Reneega Gangadhar, Soumitra Das
1. Junior Resident, Department of Pharmacology, Government TDMC, Alappuzha, Kerala, India.
2. Assistant Professor, Department of Pharmacology, Government TDMC, Alappuzha, Kerala, India.
3. Professor, Department of Pharmacology, Sree Mookambika Institute of Medical Science, Kulasekharam, Tamil Nadu, India.
4. Junior Resident, Department of Psychiatry, Government TDMC, Alappuzha, Kerala, India.
Correspondence
Dr. Dhanya Sasidharan Palappallil,
Assistant Professor, Department of Pharmacology, Government TDMCA, Kerala-688005, India.
E-mail: drspdhanya@gmail.com
Sodium valproate induced hyperammonaemic delirium with normal liver function tests is a relatively uncommon adverse effect. It may be mistaken for psychosis or worsening of mania leading to wrong diagnosis and improper management. Plasma ammonia levels should be monitored in all patients developing altered mental status after receiving valproate therapy. This is a case series of hyperammonaemic delirium due to valproate reported to the Department of Pharmacology from Department of Psychiatry over a period of one year.
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